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| Marlins | 7:05 pm ET | Nationals | | Alcantara gives up back-to-back homers, six runs in four innings as Nationals end Marlins' winning streak |
| Astros | 7:07 pm ET | Blue Jays | | Ken Giles Blames Astros |
| Orioles | 7:10 pm ET | Red Sox | | Best Red Sox team in history clinches home field throughout playoffs |
| Yankees | 7:10 pm ET | Rays | | Rays 1 Yankees 4: The Day the Music Died |
| Pirates | 8:05 pm ET | Cubs | | Overflow thread 3: Cubs vs. Pirates, Monday 9/24, 7:05 CT |
| Indians | 8:10 pm ET | White Sox | | Covey good again, but White Sox fall to Indians, Kluber |
| Brewers | 8:15 pm ET | Cardinals | | Game Thread #157: Milwaukee Brewers (89-67) @ St. Louis Cardinals (87-69) |
| Phillies | 8:40 pm ET | Rockies | | Altherr hurt, Phillies fall to .500 with 10-1 loss to Rockies |
| Dodgers | 9:40 pm ET | Diamondbacks | | Dodgers rally in seventh to move one game closer to postseason |
| Rangers | 10:07 pm ET | Angels | | Rangers fall to Angels after Jose Briceno's walk-off home run |
| Athletics | 10:10 pm ET | Mariners | | Usual suspects sink Mariners, Mighty Dee Gordon |
| Padres | 10:15 pm ET | Giants | | Giants’ Brandon Crawford saddened by Bobby Evans’ firing |
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| Royals | 6:40 pm ET | Reds | | We don't have news for this game |
| Marlins | 7:05 pm ET | Nationals | | Stephen Strasburg on penultimate outing of 2018 being a brief one, takeaways from season + more... |
| Astros | 7:07 pm ET | Blue Jays | | Game #158 Preview: James vs Gaviglio |
| Orioles | 7:10 pm ET | Red Sox | | Red Sox set franchise record for wins, clinch home field throughout playoffs |
| Yankees | 7:10 pm ET | Rays | | Yankees 4, Rays 1: Sometimes, throwing eight pitchers out there works |
| Braves | 7:10 pm ET | Mets | | Braves forge seven unanswered runs to beat Mets |
| Pirates | 8:05 pm ET | Cubs | | Overflow thread 3: Cubs vs. Pirates, Tuesday 9/25, 7:05 CT |
| Indians | 8:10 pm ET | White Sox | | Cleveland Indians, Chicago White Sox lineups for Tuesday night, Game No. 157 |
| Tigers | 8:10 pm ET | Twins | | Tigers 4, Twins 2: Joe Mauer is an On-Base god |
| Brewers | 8:15 pm ET | Cardinals | | Brewers win bullpen battle to open series at Busch |
| Phillies | 8:40 pm ET | Rockies | | Bullpen-game-Colorado Rockies top Phillies, move into Wild Card spot |
| Dodgers | 9:40 pm ET | Diamondbacks | | Snake Bytes 9/25: Headshot |
| Rangers | 10:07 pm ET | Angels | | Game 158 - Beat ‘em if you can: Pregame Picks |
| Athletics | 10:10 pm ET | Mariners | | We don't have news for this game |
| Padres | 10:15 pm ET | Giants | | San Diego Padres: Bryan Mitchell Saved His 2019 Roster Spot |
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| Marlins | 4:05 pm ET | Nationals | | We don't have news for this game |
| Astros | 4:07 pm ET | Blue Jays | | Game Thread #158: Houston Astros @ Toronto Blue Jays, September 26th, 2018 |
| Royals | 6:40 pm ET | Reds | | We don't have news for this game |
| Orioles | 7:10 pm ET | Red Sox | | Mookie Betts joins 30-30 club, Xander Bogaerts reaches 100 RBI as Boston Red Sox smack Orioles in Game 1 of doubleheader, 19-3 |
| Yankees | 7:10 pm ET | Rays | | Rays journal: Jake Faria struggles in loss to Yankees |
| Braves | 7:10 pm ET | Mets | | Mets send Syndergaard home after six innings with sickness |
| Brewers | 7:15 pm ET | Cardinals | | Gordon: Brewers are putting Cards in a tough spot |
| Pirates | 8:05 pm ET | Cubs | | We don't have news for this game |
| Indians | 8:10 pm ET | White Sox | | We don't have news for this game |
| Tigers | 8:10 pm ET | Twins | | Detroit Tigers match win total from last season beating Twins, 4-2 |
| Phillies | 8:40 pm ET | Rockies | | We don't have news for this game |
| Dodgers | 9:40 pm ET | Diamondbacks | | We don't have news for this game |
| Rangers | 10:07 pm ET | Angels | | We don't have news for this game |
| Athletics | 10:10 pm ET | Mariners | | We don't have news for this game |
| Padres | 10:15 pm ET | Giants | | We don't have news for this game |
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| Yankees | 1:10 pm ET | Rays | | Yankees 12, Rays 1: “That’s for you, bitch” |
| Phillies | 3:10 pm ET | Rockies | | We don't have news for this game |
| Astros | 7:05 pm ET | Orioles | | We don't have news for this game |
| Braves | 7:10 pm ET | Mets | | Mets earn series win over Braves after 4-1 victory |
| Pirates | 8:05 pm ET | Cubs | | Pittsburgh Pirates Lose To Split Final Series Of 2018 Against The Cubs |
| Tigers | 8:10 pm ET | Twins | | Twins 9, Tigers 3: Liriano hurt, bullpen broken |
| Indians | 8:15 pm ET | Royals | | Mondesi provides the spark and Sal walks it off in a 2-1 win over the Indians |
| Rangers | 10:10 pm ET | Mariners | | Mariners fail to entertain, lose 2-0 |
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| White Sox | 2:10 pm ET | Twins | | We don't have news for this game |
| Cardinals | 2:20 pm ET | Cubs | | Chicago Cubs vs. St. Louis Cardinals preview, Friday 9/28, 1:20 CT |
| Pirates | 6:40 pm ET | Reds | | Game 160: Pirates at Reds (6:40 PM ET) - Kingham vs. DeSclafani |
| Braves | 7:05 pm ET | Phillies | | Nein! Braves 10, Phillies 2 |
| Astros | 7:05 pm ET | Orioles | | Game Recap: Pitching, Defense Take One in Baltimore, Astros 2, O’s 1 |
| Yankees | 7:10 pm ET | Red Sox | | New York Yankees, Red Sox lineups as Didi Gregorius, Aaron Hicks return |
| Marlins | 7:10 pm ET | Mets | | WATCH: Mets' David Wright gets emotional over first at-bat since 2016 |
| Blue Jays | 7:10 pm ET | Rays | | GameThread Game #160: Blue Jays at House of Horrors |
| Tigers | 8:10 pm ET | Brewers | | Tigers vs. Brewers: Photos from final series |
| Nationals | 8:10 pm ET | Rockies | | NL West-leading Rox win 8th straight against Nats to clinch playoff spot |
| White Sox | 8:10 pm ET | Twins | | Six Pack of Stats: Twins 2, White Sox 1 (Game 1) |
| Indians | 8:15 pm ET | Royals | | One More Friday Night: Indians at Royals |
| Athletics | 10:07 pm ET | Angels | | A’s rookie Lou Trivino gets a surprise start at Anaheim |
| Rangers | 10:10 pm ET | Mariners | | Game 160 Game Day Thread - Texas Rangers @ Seattle Mariners |
| Diamondbacks | 10:10 pm ET | Padres | | Preview, #160: 9/28 @ Padres |
| Dodgers | 10:15 pm ET | Giants | | San Francisco Giants activate Chris Stratton from paternity list |
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| Yankees | 1:00 pm ET | Red Sox | | Red Sox Vs. Yankees Lineup: Mookie Betts, Xander Bogaerts Get Days Off |
| Cardinals | 1:00 pm ET | Cubs | | Saturday’s National League games that matter |
| Dodgers | 4:05 pm ET | Giants | | Dodgers clinch playoff berth with win over Giants |
| Pirates | 4:10 pm ET | Reds | | Game 161: Reds vs. Pirates (4:10 PM EDT) - Lorenzen vs. Taillon |
| Blue Jays | 6:10 pm ET | Rays | | Game #161 Preview: Borucki vs Snell |
| Braves | 7:05 pm ET | Phillies | | Braves deploy regular lineup against Nola, Phillies |
| Astros | 7:05 pm ET | Orioles | | Game Thread #160, 161: Houston Astros @ Baltimore Orioles, September 29th, 2018. |
| White Sox | 7:10 pm ET | Twins | | Is this the end? Mauer savors last Twins series of season |
| Tigers | 7:10 pm ET | Brewers | | Game Thread #161: Detroit Tigers (64-96) @ Milwaukee Brewers (93-67) |
| Marlins | 7:10 pm ET | Mets | | Open Thread: Mets vs Marlins, 9/29/18 |
| Indians | 7:15 pm ET | Royals | | Indians: A Lot, Royals: Less |
| Nationals | 8:10 pm ET | Rockies | | Wire Taps: Nationals drop opener to Rockies; Someone brings up Stephen Strasburg shutdown again... |
| Diamondbacks | 8:40 pm ET | Padres | | Arizona Diamondbacks 2, San Diego Padres 3 |
| Athletics | 9:07 pm ET | Angels | | Mike Fiers shelled in final outing as A’s fall to Angels |
| Rangers | 9:10 pm ET | Mariners | | Saturday Texas Rangers things |
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| Yankees | 3:05 pm ET | Red Sox | | Yankees vs. Red Sox: Luis Cessa vs. Rick Porcello |
| Dodgers | 3:05 pm ET | Giants | | Dodgers rout Giants, head to NL West tiebreaker vs Rockies |
| Braves | 3:05 pm ET | Phillies | | 'We will be better' in 2019, Rhys Hoskins says as Phillies end season with 3-1 win over Braves |
| Astros | 3:05 pm ET | Orioles | | Verlander helps Astros roll to doubleheader sweep of Orioles |
| Athletics | 3:07 pm ET | Angels | | No Angels manager won more than Scioscia. One more W. |
| White Sox | 3:10 pm ET | Twins | | Game 162: White Sox at Twins |
| Tigers | 3:10 pm ET | Brewers | | Brewers crush Tigers, 11-0; head to tiebreaker game against Cubs for National League Central title |
| Rangers | 3:10 pm ET | Mariners | | Mariners close out 2018 season with 3-1 win over the Texas Rangers |
| Pirates | 3:10 pm ET | Reds | | Pirates conclude season with extra-innings victory against Reds |
| Diamondbacks | 3:10 pm ET | Padres | | Arizona Diamondbacks 3, San Diego Padres 4 |
| Marlins | 3:10 pm ET | Mets | | David Wright says goodbye, Austin Jackson says goodnight in Marlins’ 1-0 walk-off loss |
| Blue Jays | 3:10 pm ET | Rays | | Jays drop season finale 9-4 |
| Nationals | 3:10 pm ET | Rockies | | Rockies rout Nats 12-0, to play at Dodgers for NL West title |
| Indians | 3:15 pm ET | Royals | | Royals drop finale to Indians, 2-1 |
| Cardinals | 3:20 pm ET | Cubs | | Overflow thread 3: Cubs vs. Cardinals, Sunday 9/30, 2:20 CT |
