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| Orioles | 7 - 6 | Red Sox | | Monday’s Red Sox-Orioles matchups: Clay Buchholz vs. Wei-Yin Chen |
| Reds | 5 - 6 | Pirates | | Pirates 6, Reds 5 |
| Royals | 3 - 4 | Indians | | Breaking: Indians beat Royals 4-3 |
| Angels | 4 - 2 | Nationals | | Game 020 - Angels @ Nationals Part 2 - Pregame Pick |
| White Sox | 3 - 1 | Tigers | | White Sox 3, Tigers 1: Anibal Sanchez starts strong, but unravels late as Chicago pulls out win in opener |
| Cardinals | 0 - 2 | Mets | | Rapid Reaction: Mets 2, Cards 0 |
| Marlins | 2 - 4 | Braves | | Braves 4, Marlins 2 (by spike) |
| Diamondbacks | 1 - 5 | Cubs | | Travis Wood — 9 Ks, 4 RBIs — carries Cubs to 5-1 win |
| Padres | 3 - 4 | Brewers | | Padres lose to Brewers 4-3 to begin 10 game road trip |
| Giants | 2 - 8 | Rockies | | Sandoval returns after one-day mental break for SF Giants |
| Rangers | 4 - 3 | Athletics | | Recap: Oakland vs. Texas |
| Astros | 7 - 2 | Mariners | | Astros 7, Mariners 2 -- Losing streak reaches seven games |
| Phillies | 7 - 0 | Dodgers | | Cliff Lee, Philadelphia Phillies shut out Los Angeles Dodgers |
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| Royals | 8 - 2 | Indians | | Royals break out of offensive slump with 8-2 win over Indians |
| Reds | 4 - 1 | Pirates | | Kwaaay-toh … |
| Angels | 7 - 2 | Nationals | | Mike Trout beats Bryce Harper in game in which Mike Trout and Bryce Harper did nothing |
| Orioles | 3 - 9 | Blue Jays | | Bullpen gives up six runs as Orioles blow another lead in 9-3 loss to the Blue Jays |
| White Sox | 6 - 8 | Tigers | | Tigers build big lead, bullpen barely holds it |
| Yankees | 9 - 3 | Red Sox | | Rapid Reaction: Yanks 9, Red Sox 3 |
| Twins | 3 - 7 | Rays | | Tailgating Game 20: Rays (9-10) Vs Twins (9-9) |
| Cardinals | 3 - 0 | Mets | | Grand Disaster: Mets offense still struggling in 3-0 loss to Cards |
| Marlins | 1 - 0 | Braves | | Jose Fernandez Ks 14, Marlins shut out Braves 1-0 |
| Diamondbacks | 2 - 9 | Cubs | | Rapid Reaction: Cubs 9, Diamondbacks 2 |
| Padres | 2 - 1 | Brewers | | 04/22 Padres Preview: Game 21 @ Brewers |
| Giants | 1 - 2 | Rockies | | Tuesday’s Giants, Rockies lineups; Plus, Perez is back in the bigs |
| Rangers | 5 - 4 | Athletics | | Choice in for Choo, batting leadoff |
| Astros | 5 - 2 | Mariners | | Game 20, Astros at Mariners |
| Phillies | 3 - 2 | Dodgers | | Rapid Reaction: Phillies 3, Dodgers 2 (F/10) |
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| Marlins | 1 - 3 | Braves | | .@ChristianYelich extends his hit streak to 17 games with a bunt single in the 8th. Marlins and Braves still tied at 1. |
| Diamondbacks | 7 - 5 | Cubs | | Ruggiano to get MRI on hamstring |
| Giants | 12 - 10 | Rockies | | Open GameThread, 4/23 |
| Rangers | 3 - 0 | Athletics | | Perez continues his stellar performance |
| Astros | 3 - 5 | Mariners | | Astros 5, Mariners 2 -- eight is not so great as the losing continues |
| Yankees | 1 - 5 | Red Sox | | Daniel Nava heading to Triple A; Red Sox to recall reliever Alex Wilson |
| Royals | 3 - 5 | Indians | | Indians trip Royals, 5-3 |
| Reds | 5 - 2 | Pirates | | Track meat |
| Angels | 4 - 5 | Nationals | | Angels give up four runs in ninth inning in 5-4 loss to Nationals |
| Orioles | 10 - 8 | Blue Jays | | Orioles hit four home runs in 10-8 victory over the Blue Jays on Wednesday night |
| White Sox | 6 - 4 | Tigers | | White Sox 6, Tigers 4: Bullpen blows up, Ian Krol serves up eighth inning grand slam |
| Twins | 6 - 4 | Rays | | Rays: |
| Cardinals | 2 - 3 | Mets | | Mets resist tinkering to end Curtis Granderson's slump |
| Padres | 2 - 5 | Brewers | | In-game blog: Brewers vs. Padres |
| Phillies | 2 - 5 | Dodgers | | Greinke sharp again as Dodgers top Phillies, 5-2 |
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| Royals | 12:05 pm ET | Indians | | Cleveland Indians vs. Kansas City Royals: Get game updates and chat live with Chris Fedor |
| Reds | 12:35 pm ET | Pirates | | Reds on deck |
| White Sox | 1:08 pm ET | Tigers | | Alex Avila gets green light to swing on 3-0 count in 9th inning, comes up short in Detroit Tigers' loss |
| Twins | 1:10 pm ET | Rays | | Twins 6, Rays 4 (12): Bullpen shows its might with seven scoreless innings |
| Cardinals | 1:10 pm ET | Mets | | Morning Briefing: Series win rests on Colon |
| Diamondbacks | 2:20 pm ET | Cubs | | Cubs collapse on Wrigley Field’s 100th birthday, fall to D-Backs |
| Padres | 7:05 pm ET | Nationals | | Opposite dugout: Light-hitting Padres pitching staff making opponents say uncle - Nationals Buzz |
| Orioles | 7:07 pm ET | Blue Jays | | Orioles hit four home runs in 10-8 victory over the Blue Jays on Wednesday night |
| Yankees | 7:10 pm ET | Red Sox | | Yankees buy happiness |
| Athletics | 8:10 pm ET | Astros | | We don't have news for this game |
| Phillies | 10:10 pm ET | Dodgers | | Dodgers 5, Phillies 2 |
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| Angels | 7:05 pm ET | Yankees | | We don't have news for this game |
| Royals | 7:05 pm ET | Orioles | | We don't have news for this game |
| Padres | 7:05 pm ET | Nationals | | We don't have news for this game |
| Red Sox | 7:07 pm ET | Blue Jays | | We don't have news for this game |
| Marlins | 7:10 pm ET | Mets | | We don't have news for this game |
| Reds | 7:35 pm ET | Braves | | We don't have news for this game |
| Tigers | 8:10 pm ET | Twins | | We don't have news for this game |
| Rays | 8:10 pm ET | White Sox | | We don't have news for this game |
| Athletics | 8:10 pm ET | Astros | | We don't have news for this game |
| Cubs | 8:10 pm ET | Brewers | | We don't have news for this game |
| Pirates | 8:15 pm ET | Cardinals | | We don't have news for this game |
| Phillies | 9:40 pm ET | Diamondbacks | | We don't have news for this game |
| Rangers | 10:10 pm ET | Mariners | | We don't have news for this game |
| Rockies | 10:10 pm ET | Dodgers | | We don't have news for this game |
| Indians | 10:15 pm ET | Giants | | We don't have news for this game |
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| Angels | 1:05 pm ET | Yankees | | We don't have news for this game |
| Padres | 1:05 pm ET | Nationals | | We don't have news for this game |
| Red Sox | 1:07 pm ET | Blue Jays | | We don't have news for this game |
| Tigers | 2:10 pm ET | Twins | | We don't have news for this game |
| Pirates | 4:05 pm ET | Cardinals | | We don't have news for this game |
| Indians | 4:05 pm ET | Giants | | We don't have news for this game |
| Royals | 7:05 pm ET | Orioles | | We don't have news for this game |
| Rays | 7:10 pm ET | White Sox | | We don't have news for this game |
| Reds | 7:10 pm ET | Braves | | We don't have news for this game |
| Athletics | 7:10 pm ET | Astros | | We don't have news for this game |
| Marlins | 7:10 pm ET | Mets | | We don't have news for this game |
| Cubs | 7:10 pm ET | Brewers | | We don't have news for this game |
| Phillies | 8:10 pm ET | Diamondbacks | | We don't have news for this game |
| Rangers | 9:10 pm ET | Mariners | | We don't have news for this game |
| Rockies | 9:10 pm ET | Dodgers | | We don't have news for this game |
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| Red Sox | 1:07 pm ET | Blue Jays | | We don't have news for this game |
| Marlins | 1:10 pm ET | Mets | | We don't have news for this game |
| Royals | 1:35 pm ET | Orioles | | We don't have news for this game |
| Reds | 1:35 pm ET | Braves | | We don't have news for this game |
| Padres | 1:35 pm ET | Nationals | | We don't have news for this game |
| Tigers | 2:10 pm ET | Twins | | We don't have news for this game |
| Rays | 2:10 pm ET | White Sox | | We don't have news for this game |
| Athletics | 2:10 pm ET | Astros | | We don't have news for this game |
| Cubs | 2:10 pm ET | Brewers | | We don't have news for this game |
| Pirates | 2:15 pm ET | Cardinals | | We don't have news for this game |
| Indians | 4:05 pm ET | Giants | | We don't have news for this game |
| Rangers | 4:10 pm ET | Mariners | | We don't have news for this game |
| Phillies | 4:10 pm ET | Diamondbacks | | We don't have news for this game |
| Rockies | 4:10 pm ET | Dodgers | | We don't have news for this game |
| Angels | 8:00 pm ET | Yankees | | We don't have news for this game |
