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| Cardinals | 7:05 pm ET | Phillies | | Altherr's two-run double in 10th lifts Phillies over Cardinals 6-5 |
| Brewers | 7:05 pm ET | Pirates | | Trevor Williams brilliant as Pirates shut out Brewers |
| White Sox | 7:10 pm ET | Indians | | White Sox, Dylan Covey trail Indians 6-0 |
| Dodgers | 8:05 pm ET | Cubs | | Cubs, Dodgers postponed; split doubleheader Tuesday |
| Rays | 8:10 pm ET | Astros | | Rays journal: A 4-0 lead disappears in loss at Houston |
| Rangers | 8:15 pm ET | Royals | | Kansas City Royals trade Kelvin Herrera to Washington Nationals |
| Mets | 8:40 pm ET | Rockies | | Jay Bruce had this off-day decision made for him |
| Diamondbacks | 10:07 pm ET | Angels | | Arizona Diamondbacks 7, Los Angeles Angels 4 |
| Marlins | 10:15 pm ET | Giants | | Giants’ top pick Joey Bart tours AT&T Park, meets Buster Posey |
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| Mariners | 7:05 pm ET | Yankees | | Yankees 7, Mariners 2: Dominant Domingo and the Dingers |
| Cardinals | 7:05 pm ET | Phillies | | Philadelphia Phillies vs St. Louis Cardinals: How to watch online, lineups, and more |
| Brewers | 7:05 pm ET | Pirates | | Pirates comeback falls short in 3-2 loss to Brewers |
| Orioles | 7:05 pm ET | Nationals | | Nationals rally from 5-1 deficit for 9-7 win over O’s: Trea Turner 4 for 4, on a big night in D.C. |
| Braves | 7:07 pm ET | Blue Jays | | Braves News: Atlanta turns to Soroka in opener of Blue Jays series |
| White Sox | 7:10 pm ET | Indians | | Carlos Rodon looks to help White Sox halt 5-game losing streak |
| Tigers | 7:10 pm ET | Reds | | Game 74 Preview: Tigers at Reds |
| Dodgers | 8:05 pm ET | Cubs | | Dodgers take anger out on Cubs reliever, rally for 4-3 win |
| Red Sox | 8:10 pm ET | Twins | | Boston Red Sox lose as Twins No. 9 hitter Ryan LaMarre starts both rallies (vs. Chris Sale, Robby Scott) |
| Rays | 8:10 pm ET | Astros | | Rays' Kevin Kiermaier returns, with energy to spare |
| Rangers | 8:15 pm ET | Royals | | 31-44 - Kiner-Falefa takes advantage as Rangers beat Royals 4-1 |
| Mets | 8:40 pm ET | Rockies | | Colorado Rockies: If you can’t beat Jacob deGrom, trade for him |
| Diamondbacks | 10:07 pm ET | Angels | | Felix Pena proves his mettle in MLB debut, Kole Calhoun comes back with a bang & Angels beat Arizona 5-4 |
| Athletics | 10:10 pm ET | Padres | | San Diego Padres Welcome the Oakland A’s for a Two-Game Set |
| Marlins | 10:15 pm ET | Giants | | Game Thread #74: Marlins at Giants |
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| Tigers | 12:35 pm ET | Reds | | Drew VerHagen broke his nose, is now on the DL |
| Braves | 12:37 pm ET | Blue Jays | | Video: Camargo, Culberson lead Braves past Blue Jays |
| Cardinals | 1:05 pm ET | Phillies | | Odubel Herrera's homer, Adam Morgan's save give Phillies 4-3 win over Cardinals |
| White Sox | 1:10 pm ET | Indians | | Renteria ejected in White Sox’ 12-0 loss |
| Dodgers | 2:20 pm ET | Cubs | | Chicago Cubs: Brandon Morrow is heading to the disabled list |
| Athletics | 3:40 pm ET | Padres | | San Diego Padres: Joey Fuego Back on the Hill, Mitchell to DL |
| Marlins | 3:45 pm ET | Giants | | Giants use five-run inning to sink Marlins, win series |
| Mariners | 7:05 pm ET | Yankees | | Looking back at the Yankees-Mariners playoffs series of years past |
| Brewers | 7:05 pm ET | Pirates | | Pirates and Brewers postponed due to rain, no makeup date announced |
| Orioles | 7:05 pm ET | Nationals | | Orioles leading 2-0 in Washington with game delayed by rain |
| Red Sox | 8:10 pm ET | Twins | | Second thoughts: Red Sox need to upgrade |
| Rays | 8:10 pm ET | Astros | | Game Recap: Rings and Dingers Galore at Minute Maid Park as Astros Beat Rays 5-1 |
| Rangers | 8:15 pm ET | Royals | | Watch: Isiah Kiner-Falefa's game-sealing throw nearly took off Jake Diekman's head in Rangers win |
| Mets | 8:40 pm ET | Rockies | | Mets: Making sense of the hypothetical Jay Bruce for Bryan Shaw trade proposal |
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| Mariners | 1:05 pm ET | Yankees | | Yankees injuries: A.J. Cole placed on disabled list, Luis Cessa activated |
| Red Sox | 1:10 pm ET | Twins | | Eddie Rosario scratched from lineup as Twins go for sweep of Red Sox |
| Mets | 3:10 pm ET | Rockies | | Rockies win series with 6-4 victory over Mets |
| Diamondbacks | 7:05 pm ET | Pirates | | D-backs 9, Pirates 3 - Easy Game, Easy Life |
| Orioles | 7:05 pm ET | Nationals | | Soto’s 2-run double carries Nationals past Orioles 4-2 |
| Cubs | 7:10 pm ET | Reds | | Jesse Winker's first grand slam lifts Cincinnati Reds over Chicago Cubs 6-2 |
| Athletics | 8:10 pm ET | White Sox | | Rain forces White Sox to cancel Thursday's game vs. Athletics |
| Cardinals | 8:10 pm ET | Brewers | | Wrong statement for Martinez, Cards in blowout loss to Brewers |
| Blue Jays | 10:07 pm ET | Angels | | Blue Jays: Aaron Sanchez leaves game with finger injury |
| Padres | 10:15 pm ET | Giants | | Bumgarner throws eight scoreless innings as Giants beat Padres, 3-0 |
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| Diamondbacks | 7:05 pm ET | Pirates | | Game #75, June 22: Diamondbacks @ Pirates |
| Phillies | 7:05 pm ET | Nationals | | Phillies vs. Nationals Series Preview: NL East clash could prove important in the standings |
| Yankees | 7:10 pm ET | Rays | | Tampa Bay Rays activate Daniel Robertson, option Austin Pruitt |
| Tigers | 7:10 pm ET | Indians | | Photos: Tigers vs. Indians series |
| Mariners | 7:10 pm ET | Red Sox | | Boston Red Sox overcome disastrous Wright start in wild 14-10 comeback win vs. Mariners |
| Cubs | 7:10 pm ET | Reds | | Cincinnati Reds: News and notes from Blog Red Machine – June 22, 2018 |
| Dodgers | 7:10 pm ET | Mets | | Final Score: Dodgers 5, Mets 2—Business as usual |
| Orioles | 7:35 pm ET | Braves | | Can Braves clobber Cobb in Cobb County in Orioles opener? |
| Athletics | 8:10 pm ET | White Sox | | A’s reinstate Matt Joyce, will add Danny Coulombe for Game 2 |
| Rangers | 8:10 pm ET | Twins | | We don't have news for this game |
| Cardinals | 8:10 pm ET | Brewers | | FanPost Friday: Construct the ideal Cubs trade |
| Royals | 8:10 pm ET | Astros | | Royals vs. Astros Friday Open thread |
| Marlins | 8:40 pm ET | Rockies | | Rockies Insider: With dismal Marlins in town, Colorado must fry the fish and continue to gain momentum at Coors Field |
| Blue Jays | 10:07 pm ET | Angels | | Disastrous umpiring job overshadows gritty Angels 2-1 victory over Jays |
| Padres | 10:15 pm ET | Giants | | Bumgarner goes 8 innings for 1st win, Giants beat Padres 3-0 |
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| Athletics | 2:10 pm ET | White Sox | | A’s split doubleheader after Barreto stars in Game 1 |
| Rangers | 2:10 pm ET | Twins | | Rangers 8, Twins 1: Major Minor fail |
| Marlins | 3:10 pm ET | Rockies | | Gray strikes out 12 in Rockies' 11-3 win over Marlins |
| Padres | 4:05 pm ET | Giants | | Richard sets down 18 of 21 in Padres' 6-2 win over Giants |
| Diamondbacks | 4:05 pm ET | Pirates | | Pittsburgh Pirates Fall In 13 Innings Against The Arizona Diamondbacks |
| Phillies | 4:05 pm ET | Nationals | | All-Star Odubel: Phillies 12, Nationals 2 |
| Yankees | 4:10 pm ET | Rays | | Yankees 1, Rays 2: Offense no-shows series opener in Tampa |
| Cardinals | 4:10 pm ET | Brewers | | Jesus Aguilar’s two home runs give Milwaukee Brewers 2-1 walkoff win over Cardinals |
| Cubs | 4:10 pm ET | Reds | | Red hot Reds beat Cubs 6-3 for their fifth straight win and eighth in their last 10 games |
| Orioles | 4:10 pm ET | Braves | | Braves rally after bullpen collapse in ninth, but lose to Orioles in 15 innings |
| Tigers | 6:10 pm ET | Indians | | Detroit Tigers vs. Cleveland Indians: Time, TV, game info |
| Mariners | 7:15 pm ET | Red Sox | | Mariners and Red Sox forget how to pitch, Mariners forget more |
| Royals | 7:15 pm ET | Astros | | Game Recap: Royal Shutout. Kansas City Kings of the Mound hold Astros Scoreless, 1-0 |
| Dodgers | 7:15 pm ET | Mets | | Bellinger slams sinking Mets; Dodgers win 5-2 behind Wood |
| Blue Jays | 9:07 pm ET | Angels | | Solid outing by Heaney leads Angels past Blue Jays 2-1 |
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| Mariners | 1:05 pm ET | Red Sox | | We don't have news for this game |
| Yankees | 1:10 pm ET | Rays | | We don't have news for this game |
| Tigers | 1:10 pm ET | Indians | | We don't have news for this game |
| Cubs | 1:10 pm ET | Reds | | We don't have news for this game |
| Dodgers | 1:10 pm ET | Mets | | We don't have news for this game |
| Diamondbacks | 1:35 pm ET | Pirates | | We don't have news for this game |
| Phillies | 1:35 pm ET | Nationals | | We don't have news for this game |
| Orioles | 1:35 pm ET | Braves | | We don't have news for this game |
| Athletics | 2:10 pm ET | White Sox | | We don't have news for this game |
| Rangers | 2:10 pm ET | Twins | | We don't have news for this game |
| Cardinals | 2:10 pm ET | Brewers | | We don't have news for this game |
| Royals | 2:10 pm ET | Astros | | We don't have news for this game |
| Marlins | 3:10 pm ET | Rockies | | We don't have news for this game |
| Padres | 4:05 pm ET | Giants | | We don't have news for this game |
| Blue Jays | 4:07 pm ET | Angels | | We don't have news for this game |
