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| Phillies | 7:05 pm ET | Nationals | | Phillies and Nationals open rare five-game set |
| Orioles | 7:07 pm ET | Blue Jays | | We don't have news for this game |
| Red Sox | 7:10 pm ET | Rays | | Rays 7, Red Sox 4: Series win secured |
| Marlins | 7:10 pm ET | Mets | | Final Score: Marlins 8, Mets 4-This is the end |
| Cardinals | 9:40 pm ET | Diamondbacks | | Photos: Arizona Diamondbacks vs. St. Louis Cardinals |
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| Phillies | 1:05 pm ET | Nationals | | Game Thread 9/23: Phillies at Nationals |
| Twins | 6:40 pm ET | Tigers | | Spencer Turnbull finds old form, but Detroit Tigers lose again, 4-2 |
| Brewers | 6:40 pm ET | Reds | | Cincinnati Reds' Marty Brennaman left a big imprint on today's broadcasters |
| Cubs | 7:05 pm ET | Pirates | | Pirates snap long losing streak with 9-2 win over Cubs |
| Phillies | 7:05 pm ET | Nationals | | Squeezed: Nationals 6, Phillies 5 |
| Orioles | 7:07 pm ET | Blue Jays | | We don't have news for this game |
| Yankees | 7:10 pm ET | Rays | | Cameron Maybin's homer give New York Yankees lead on Tampa Bay Rays Tuesday |
| Marlins | 7:10 pm ET | Mets | | Mets to retire Jerry Koosman’s number 36 during 2020 season. |
| Red Sox | 8:05 pm ET | Rangers | | Game 157 Game Day Thread - Boston Red Sox @ Texas Rangers |
| Indians | 8:10 pm ET | White Sox | | Cleveland Indians: Jose Ramirez officially rejoins lineup |
| Braves | 8:15 pm ET | Royals | | Mike Soroka’s start pushed to Sunday, seems likely for Game 3 of NLDS |
| Cardinals | 9:40 pm ET | Diamondbacks | | Milwaukee Brewers pennant race tracker: Still 6 games to go |
| Rockies | 9:45 pm ET | Giants | | Game no. 157 thread: Jeff Hoffman vs. Madison Bumgarner |
| Athletics | 10:07 pm ET | Angels | | ‘It’s always been tight, and it’s going to continue to be tight’: the wild card race gains speed in Athletics loss to Angels |
| Astros | 10:10 pm ET | Mariners | | Gerritt Cole crashes the Astros single-season K record. Slashes Mariners lineup, 3-0 |
| Dodgers | 10:10 pm ET | Padres | | Rich Hill marks his return with gutsy performance in Dodgers' win over Padres |
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| Cardinals | 3:40 pm ET | Diamondbacks | | St. Louis Cardinals: Wacha’s biggest start of the year |
| Twins | 6:40 pm ET | Tigers | | Game 157 Preview: Twins at Tigers |
| Brewers | 6:40 pm ET | Reds | | Brewers clinch playoff birth with 9-2 win over the Reds |
| Cubs | 7:05 pm ET | Pirates | | Pittsburgh Pirates Defeat Chicago Cubs 4-2 |
| Phillies | 7:05 pm ET | Nationals | | Should Bryce Harper regret signing with the Phillies? |
| Orioles | 7:07 pm ET | Blue Jays | | We don't have news for this game |
| Yankees | 7:10 pm ET | Rays | | Rays 4, Yankees 0: One Hit Wonder |
| Marlins | 7:10 pm ET | Mets | | Mets' Jacob deGrom says Cy Young was on the back of his mind during 'weird' outing |
| Red Sox | 8:05 pm ET | Rangers | | Texas Rangers lineup for September 25, 2019 |
| Indians | 8:10 pm ET | White Sox | | Cleveland Indians: Ramirez drives in seven in 11-0 romp |
| Braves | 8:15 pm ET | Royals | | Untitled |
| Rockies | 9:45 pm ET | Giants | | Rockies 8, Giants 5 (16 innings): Charlie Blackmon’s homer wins it for the Rockies. |
| Athletics | 10:07 pm ET | Angels | | Matt Chapman hits go-ahead homer in ninth inning, Athletics beat Angels |
| Astros | 10:10 pm ET | Mariners | | Astros' Greinke has no-hitter through 6th against Mariners |
| Dodgers | 10:10 pm ET | Padres | | Dodgers Injury Update: Dave Roberts Hopeful Joe Kelly Will Pitch Thursday Vs. Padres |
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| Brewers | 12:35 pm ET | Reds | | What We Learned: Postseason clinching roundup |
| Twins | 1:10 pm ET | Tigers | | Detroit Tigers score vs. Minnesota Twins: Scoring updates |
| Red Sox | 2:05 pm ET | Rangers | | 76-83 - Minor gets his milestone in Rangers’ 7-5 finale win over Boston |
| Dodgers | 3:40 pm ET | Padres | | Clayton Kershaw and the Dodgers' bullpen sharp in brisk shutout over the Padres |
| Rockies | 3:45 pm ET | Giants | | Giants 2, Rockies 1: Giants avenge 16-inning loss with a walk-off |
| Phillies | 4:05 pm ET | Nationals | | I’m outta here |
| Cubs | 7:05 pm ET | Pirates | | Pittsburgh Pirates Finish Off Sweep Of Chicago Cubs |
| Marlins | 7:10 pm ET | Mets | | Final Score: Marlins 4, Mets 2 — Wheels Come Off |
| Indians | 8:10 pm ET | White Sox | | We don't have news for this game |
| Astros | 10:07 pm ET | Angels | | Game Thread 159. Sept 26th, 2019 9:07 CDT. Astros vs Angels |
| Athletics | 10:10 pm ET | Mariners | | Matt Chapman homers in back-to-back games, Athletics top Felix Hernandez and Mariners |
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| Tigers | 4:40 pm ET | White Sox | | We don't have news for this game |
| Indians | 7:05 pm ET | Nationals | | Athletics cinch wild card spot with Cleveland Indians loss |
| Reds | 7:05 pm ET | Pirates | | Pirate Kevin Newman sinks Reds all by himself |
| Marlins | 7:05 pm ET | Phillies | | Marlins vs. Phillies: Start time, how to watch, game thread and Fish Picks—September 27, 2019 |
| Rays | 7:07 pm ET | Blue Jays | | We don't have news for this game |
| Orioles | 7:10 pm ET | Red Sox | | We don't have news for this game |
| Braves | 7:10 pm ET | Mets | | Behind Stroman, Mets Play Longball to beat Braves 4-2 |
| Yankees | 8:05 pm ET | Rangers | | Yankees Highlights: Bombers smash six homers but Paxton exits |
| Brewers | 8:10 pm ET | Rockies | | Colorado Rockies 11, Milwaukee Brewers 7: Big sixth inning powers Rockies to win |
| Tigers | 8:10 pm ET | White Sox | | White Sox-Tigers doubleheader rained out |
| Cubs | 8:15 pm ET | Cardinals | | Overflow thread 3: Cubs vs. Cardinals, Friday 9/27, 7:15 CT |
| Twins | 8:15 pm ET | Royals | | Minnesota Twins Series Preview: Fin |
| Padres | 9:40 pm ET | Diamondbacks | | Photos: Padres at Diamondbacks |
| Astros | 10:07 pm ET | Angels | | Game Thread 160, Sept 27th, 2019, 9:07 CDT. Astros vs Angels. |
| Athletics | 10:10 pm ET | Mariners | | Breaking down Sean Manaea’s improvements and wild card start candidacy |
| Dodgers | 10:15 pm ET | Giants | | Dodgers At Giants: Odds And MLB Betting Trends For Final Series Of 2019 Season |
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| Orioles | 1:05 pm ET | Red Sox | | We don't have news for this game |
| Rays | 3:07 pm ET | Blue Jays | | Tampa Bay Rays to activate Yandy Diaz, per report |
| Indians | 4:05 pm ET | Nationals | | Daily Wild Card Update: September 28th (Let’s Get Wild) |
| Dodgers | 4:05 pm ET | Giants | | Hyun-Jin Ryu clinches ERA title with seven scoreless innings in Dodgers win |
| Marlins | 6:05 pm ET | Phillies | | Marlins vs. Phillies: Start time, how to watch, game thread and Fish Picks—September 28, 2019 |
| Reds | 7:05 pm ET | Pirates | | Reds at Pirates, Game 2 - Preview and Lineups |
| Tigers | 7:10 pm ET | White Sox | | Gamethread: Tigers at White Sox |
| Braves | 7:10 pm ET | Mets | | Seth Lugo keeps open mind to Mets future as reliever or starter |
| Cubs | 7:15 pm ET | Cardinals | | Cubs 8, Cardinals 2: Where was this last weekend? |
| Twins | 7:15 pm ET | Royals | | 2019 Penultimate gamethread: Twins at Royals |
| Yankees | 8:05 pm ET | Rangers | | Saturday morning Rangers things |
| Brewers | 8:10 pm ET | Rockies | | Brewers’ Comeback Thwarted in Loss to Colorado |
| Padres | 8:10 pm ET | Diamondbacks | | D-Backs' Torey Lovullo on Jake Lamb's go-ahead homer in win vs. Padres |
| Astros | 9:07 pm ET | Angels | | Astros clip Angels, 4-0, clinch homefield through ALCS |
| Athletics | 9:10 pm ET | Mariners | | Mariners walk off in ninth, A’s clinch day has awkward ending |
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| Orioles | 3:05 pm ET | Red Sox | | We don't have news for this game |
| Indians | 3:05 pm ET | Nationals | | We don't have news for this game |
| Rangers | 3:05 pm ET | Yankees | | We don't have news for this game |
| Yankees | 3:05 pm ET | Rangers | | Sunday morning Rangers things |
| Reds | 3:05 pm ET | Pirates | | Cincinnati Reds bullpen ends 5-game losing streak after 12-inning win in Pittsburgh |
| Marlins | 3:05 pm ET | Phillies | | Marlins vs. Phillies: Start time, how to watch, game thread and Fish Picks—September 29, 2019 |
| Dodgers | 3:05 pm ET | Giants | | Giants can’t beat L.A. in Bochy’s final game |
| Astros | 3:07 pm ET | Angels | | Game Thread 161. September 28, 2019, 8:07 CDT, Astros vs Angels |
| Rays | 3:07 pm ET | Blue Jays | | Rays 3 Blue Jays 8: 162/162 |
| Athletics | 3:10 pm ET | Mariners | | Athletics lose Game 162 against Mariners |
| Brewers | 3:10 pm ET | Rockies | | Milwaukee Brewers pennant race tracker: 1 game to go |
| Tigers | 3:10 pm ET | White Sox | | Sox end on a high note, 5-3 |
| Braves | 3:10 pm ET | Mets | | Mike Soroka will make final start as Braves wrap up regular season against Mets |
| Padres | 3:10 pm ET | Diamondbacks | | Taijuan Walker returns as Diamondbacks finish season with series sweep of Padres |
| Cubs | 3:15 pm ET | Cardinals | | Chicago Cubs vs. St. Louis Cardinals preview, Sunday 9/29, 2:15 CT |
| Twins | 3:15 pm ET | Royals | | Finale: Royals 5, Twins 4 |
