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| Orioles | 7 - 6 | Red Sox | | Monday’s Red Sox-Orioles matchups: Clay Buchholz vs. Wei-Yin Chen |
| Reds | 5 - 6 | Pirates | | Pirates 6, Reds 5 |
| Royals | 3 - 4 | Indians | | Breaking: Indians beat Royals 4-3 |
| Angels | 4 - 2 | Nationals | | Game 020 - Angels @ Nationals Part 2 - Pregame Pick |
| White Sox | 3 - 1 | Tigers | | White Sox 3, Tigers 1: Anibal Sanchez starts strong, but unravels late as Chicago pulls out win in opener |
| Cardinals | 0 - 2 | Mets | | Rapid Reaction: Mets 2, Cards 0 |
| Marlins | 2 - 4 | Braves | | Braves 4, Marlins 2 (by spike) |
| Diamondbacks | 1 - 5 | Cubs | | Travis Wood — 9 Ks, 4 RBIs — carries Cubs to 5-1 win |
| Padres | 3 - 4 | Brewers | | Padres lose to Brewers 4-3 to begin 10 game road trip |
| Giants | 2 - 8 | Rockies | | Sandoval returns after one-day mental break for SF Giants |
| Rangers | 4 - 3 | Athletics | | Recap: Oakland vs. Texas |
| Astros | 7 - 2 | Mariners | | Astros 7, Mariners 2 -- Losing streak reaches seven games |
| Phillies | 7 - 0 | Dodgers | | Cliff Lee, Philadelphia Phillies shut out Los Angeles Dodgers |
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| Royals | 8 - 2 | Indians | | Royals break out of offensive slump with 8-2 win over Indians |
| Reds | 4 - 1 | Pirates | | Kwaaay-toh … |
| Angels | 7 - 2 | Nationals | | Mike Trout beats Bryce Harper in game in which Mike Trout and Bryce Harper did nothing |
| Orioles | 3 - 9 | Blue Jays | | Bullpen gives up six runs as Orioles blow another lead in 9-3 loss to the Blue Jays |
| White Sox | 6 - 8 | Tigers | | Tigers build big lead, bullpen barely holds it |
| Yankees | 9 - 3 | Red Sox | | Rapid Reaction: Yanks 9, Red Sox 3 |
| Twins | 3 - 7 | Rays | | Tailgating Game 20: Rays (9-10) Vs Twins (9-9) |
| Cardinals | 3 - 0 | Mets | | Grand Disaster: Mets offense still struggling in 3-0 loss to Cards |
| Marlins | 1 - 0 | Braves | | Jose Fernandez Ks 14, Marlins shut out Braves 1-0 |
| Diamondbacks | 2 - 9 | Cubs | | Rapid Reaction: Cubs 9, Diamondbacks 2 |
| Padres | 2 - 1 | Brewers | | 04/22 Padres Preview: Game 21 @ Brewers |
| Giants | 1 - 2 | Rockies | | Tuesday’s Giants, Rockies lineups; Plus, Perez is back in the bigs |
| Rangers | 5 - 4 | Athletics | | Choice in for Choo, batting leadoff |
| Astros | 5 - 2 | Mariners | | Game 20, Astros at Mariners |
| Phillies | 3 - 2 | Dodgers | | Rapid Reaction: Phillies 3, Dodgers 2 (F/10) |
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| Marlins | 12:10 pm ET | Braves | | Miami Marlins: Christian Yelich downplays 16-game hitting streak |
| Diamondbacks | 2:20 pm ET | Cubs | | We don't have news for this game |
| Giants | 3:10 pm ET | Rockies | | Bumgarner pitches well in Giants' 2-1 loss |
| Rangers | 3:35 pm ET | Athletics | | Wilson makes amends in Rangers' win |
| Astros | 3:40 pm ET | Mariners | | Astros 5, Mariners 2 -- eight is not so great as the losing continues |
| Yankees | 7:00 pm ET | Red Sox | | Red Sox Notebook: Slumping Daniel Nava may be left out |
| Royals | 7:05 pm ET | Indians | | Kansas City Royals 8, Cleveland Indians 2: Small crowd watches Danny Salazar struggle |
| Reds | 7:05 pm ET | Pirates | | Reds on deck |
| Angels | 7:05 pm ET | Nationals | | How Tom Sherrill caught Albert Pujols’s 500th home run, gave up the ball |
| Orioles | 7:07 pm ET | Blue Jays | | Blue Jays requested check of Miguel Gonzalez's glove for foreign substance |
| White Sox | 7:08 pm ET | Tigers | | Tigers 8, White Sox 6: Seems like old times - Justin Verlander and Miguel Cabrera lead victory |
| Twins | 7:10 pm ET | Rays | | Twins 3, Rays 7: Twins were Out-Priced |
| Cardinals | 7:10 pm ET | Mets | | What’s on Tap: Niese takes on Cardinals at 7:10 pm |
| Padres | 8:10 pm ET | Brewers | | Headley’s Homer In The Twelfth Lifts Padres Over Brewers |
| Phillies | 10:10 pm ET | Dodgers | | Phillies 3, Dodgers 2 (10 innings) |
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| Royals | 12:05 pm ET | Indians | | We don't have news for this game |
| Reds | 12:35 pm ET | Pirates | | We don't have news for this game |
| White Sox | 1:08 pm ET | Tigers | | We don't have news for this game |
| Twins | 1:10 pm ET | Rays | | We don't have news for this game |
| Cardinals | 1:10 pm ET | Mets | | We don't have news for this game |
| Diamondbacks | 2:20 pm ET | Cubs | | We don't have news for this game |
| Padres | 7:05 pm ET | Nationals | | We don't have news for this game |
| Orioles | 7:07 pm ET | Blue Jays | | We don't have news for this game |
| Yankees | 7:10 pm ET | Red Sox | | We don't have news for this game |
| Athletics | 8:10 pm ET | Astros | | We don't have news for this game |
| Phillies | 10:10 pm ET | Dodgers | | We don't have news for this game |
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| Angels | 7:05 pm ET | Yankees | | We don't have news for this game |
| Royals | 7:05 pm ET | Orioles | | We don't have news for this game |
| Padres | 7:05 pm ET | Nationals | | We don't have news for this game |
| Red Sox | 7:07 pm ET | Blue Jays | | We don't have news for this game |
| Marlins | 7:10 pm ET | Mets | | We don't have news for this game |
| Reds | 7:35 pm ET | Braves | | We don't have news for this game |
| Tigers | 8:10 pm ET | Twins | | We don't have news for this game |
| Rays | 8:10 pm ET | White Sox | | We don't have news for this game |
| Athletics | 8:10 pm ET | Astros | | We don't have news for this game |
| Cubs | 8:10 pm ET | Brewers | | We don't have news for this game |
| Pirates | 8:15 pm ET | Cardinals | | We don't have news for this game |
| Phillies | 9:40 pm ET | Diamondbacks | | We don't have news for this game |
| Rangers | 10:10 pm ET | Mariners | | We don't have news for this game |
| Rockies | 10:10 pm ET | Dodgers | | We don't have news for this game |
| Indians | 10:15 pm ET | Giants | | We don't have news for this game |
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| Angels | 1:05 pm ET | Yankees | | We don't have news for this game |
| Padres | 1:05 pm ET | Nationals | | We don't have news for this game |
| Red Sox | 1:07 pm ET | Blue Jays | | We don't have news for this game |
| Tigers | 2:10 pm ET | Twins | | We don't have news for this game |
| Pirates | 4:05 pm ET | Cardinals | | We don't have news for this game |
| Indians | 4:05 pm ET | Giants | | We don't have news for this game |
| Royals | 7:05 pm ET | Orioles | | We don't have news for this game |
| Rays | 7:10 pm ET | White Sox | | We don't have news for this game |
| Reds | 7:10 pm ET | Braves | | We don't have news for this game |
| Athletics | 7:10 pm ET | Astros | | We don't have news for this game |
| Marlins | 7:10 pm ET | Mets | | We don't have news for this game |
| Cubs | 7:10 pm ET | Brewers | | We don't have news for this game |
| Phillies | 8:10 pm ET | Diamondbacks | | We don't have news for this game |
| Rangers | 9:10 pm ET | Mariners | | We don't have news for this game |
| Rockies | 9:10 pm ET | Dodgers | | We don't have news for this game |
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| Red Sox | 1:07 pm ET | Blue Jays | | We don't have news for this game |
| Marlins | 1:10 pm ET | Mets | | We don't have news for this game |
| Royals | 1:35 pm ET | Orioles | | We don't have news for this game |
| Reds | 1:35 pm ET | Braves | | We don't have news for this game |
| Padres | 1:35 pm ET | Nationals | | We don't have news for this game |
| Tigers | 2:10 pm ET | Twins | | We don't have news for this game |
| Rays | 2:10 pm ET | White Sox | | We don't have news for this game |
| Athletics | 2:10 pm ET | Astros | | We don't have news for this game |
| Cubs | 2:10 pm ET | Brewers | | We don't have news for this game |
| Pirates | 2:15 pm ET | Cardinals | | We don't have news for this game |
| Indians | 4:05 pm ET | Giants | | We don't have news for this game |
| Rangers | 4:10 pm ET | Mariners | | We don't have news for this game |
| Phillies | 4:10 pm ET | Diamondbacks | | We don't have news for this game |
| Rockies | 4:10 pm ET | Dodgers | | We don't have news for this game |
| Angels | 8:00 pm ET | Yankees | | We don't have news for this game |
