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| Orioles | 4:10 pm ET | Tigers | | Tyler Alexander stars as Detroit Tigers top Orioles, 5-2, in series finale |
| White Sox | 7:40 pm ET | Twins | | We don't have news for this game |
| Padres | 7:40 pm ET | Brewers | | Garrett Richards loses to Brewers in Padres debut that could be considered larger victory |
| Nationals | 7:45 pm ET | Cardinals | | The Cardinals and Nationals play this week. Which team should Cubs fans root for? |
| Reds | 8:05 pm ET | Cubs | | Kyle Schwarber’s 3-run homer leads Cubs past Reds 8-2 |
| Mets | 8:40 pm ET | Rockies | | NY Mets falls to Rockies, 9-4; fall five games back in wild-card race |
| Marlins | 9:40 pm ET | Diamondbacks | | Robbie Ray dominates as Diamondbacks score more than three runs, rally for win |
| Royals | 10:07 pm ET | Athletics | | Athletics see six-game win streak snapped by Royals |
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| Angels | 6:35 pm ET | Yankees | | Dellin Betances has a tear in his Achilles' tendon, Yankees announce |
| Blue Jays | 7:05 pm ET | Orioles | | We don't have news for this game |
| Mariners | 7:05 pm ET | Pirates | | Pittsburgh Pirates Blown Out In Series Opener vs Seattle Mariners |
| Tigers | 7:10 pm ET | Indians | | Cleveland Indians take care of business against Tigers on Tuesday |
| Giants | 7:10 pm ET | Red Sox | | Mike Yastrzemski receives standing ovation from Red Sox fans in Fenway Park debut |
| Phillies | 7:20 pm ET | Braves | | Comeback bid falls short for Braves in 5-4 loss to Phillies |
| White Sox | 7:40 pm ET | Twins | | Say it ain’t so, Gio |
| Padres | 7:40 pm ET | Brewers | | Brewers top Padres 3-1; hottest team in the big leagues keeps rolling with 11th win in last 12 games |
| Nationals | 7:45 pm ET | Cardinals | | Ozuna powers Cardinals over Nationals |
| Reds | 8:00 pm ET | Cubs | | Aristides Aquino ends homer drought, Sonny Gray superb in Cincinnati Reds win over Chicago Cubs |
| Rangers | 8:10 pm ET | Astros | | Verlander presents more evidence in his case for Cy Young. Astros 3 homers beat Rangers 4-1 |
| Mets | 8:40 pm ET | Rockies | | Marcus Stroman aims to get Mets back on track Tuesday at Rockies at 8:40 p.m. on SNY |
| Marlins | 9:40 pm ET | Diamondbacks | | Marlins vs. Diamondbacks: Start time, how to watch, game thread and Fish Picks—September 17, 2019 |
| Royals | 10:07 pm ET | Athletics | | Scoreboard Watching: AL playoff race continues to develop with Yankees off |
| Rays | 10:10 pm ET | Dodgers | | How To Watch Tampa Bay Rays-Dodgers MLB Game Of The Week Live On YouTube |
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| Nationals | 1:15 pm ET | Cardinals | | Cardinals offense absent in loss to Nationals |
| Mets | 3:10 pm ET | Rockies | | Mets Takeaways from Wednesday's 7-4 win over the Rockies, including a ninth-inning comeback |
| Royals | 3:37 pm ET | Athletics | | Athletics walk off in the 11th inning to claim series against Kansas City Royals |
| Marlins | 3:40 pm ET | Diamondbacks | | Kevin Ginkel’s save vs. Marlins caps unexpected rise through Diamondbacks system |
| Angels | 6:35 pm ET | Yankees | | Yankees Highlights: Sabathia says farewell, Bombers fail to clinch with a win |
| Blue Jays | 7:05 pm ET | Orioles | | Blue Jays: Cavan Biggio hits for the third cycle in franchise history |
| Mariners | 7:05 pm ET | Pirates | | Rookie goes deep again as M’s beat Pirates, 4-1 |
| Tigers | 7:10 pm ET | Indians | | Indians 2, Tigers 1: Sixteen losses in a row |
| Giants | 7:10 pm ET | Red Sox | | Giants will never play another game like their 15-inning win at Fenway Park |
| Phillies | 7:20 pm ET | Braves | | Five-run frame enough to lift Phillies to vital win over Braves |
| White Sox | 7:40 pm ET | Twins | | ‘Memento’ of a lost season |
| Padres | 7:40 pm ET | Brewers | | What We Learned: Winning streak up to 4 straight, 11 of 12 |
| Reds | 8:05 pm ET | Cubs | | Iglesias hit, Iglesias save secure Reds season series win at Wrigley Field |
| Rangers | 8:10 pm ET | Astros | | Astros sweep Rangers. Take 2nd game 3-2 |
| Rays | 8:10 pm ET | Dodgers | | Kevin Cash needs to stop counting his chickens before they hatch |
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| Phillies | 12:10 pm ET | Braves | | NoLa: Braves 5, Phillies 4 |
| Mariners | 12:35 pm ET | Pirates | | Mariners defeat Pirates in 11 innings to complete sweep |
| Giants | 1:05 pm ET | Red Sox | | Watch: HOF Yaz throws first pitch to SF Giants grandson |
| Padres | 4:10 pm ET | Brewers | | What We Learned: Bad bounce and quiet offense looms in loss |
| Angels | 6:35 pm ET | Yankees | | Yankees clinch division, win 100th game in rout of Angels |
| Blue Jays | 7:05 pm ET | Orioles | | We don't have news for this game |
| Tigers | 7:10 pm ET | Indians | | Detroit Tigers shut out, 7-0, by Cleveland in 17th straight loss to Indians |
| Cardinals | 7:15 pm ET | Cubs | | Cubs activate Craig Kimbrel from injured list |
| Royals | 7:40 pm ET | Twins | | Home runs doom Royals in 8-5 loss |
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| Cardinals | 2:20 pm ET | Cubs | | Chicago Cubs vs. St. Louis Cardinals preview, Friday 9/20, 1:20 CT |
| Blue Jays | 7:05 pm ET | Yankees | | Blue Jays claim pitcher Ryan Dull off waivers from Yankees |
| Mariners | 7:05 pm ET | Orioles | | Lewis homers, Felix struggles, Mariners lose to Orioles |
| White Sox | 7:10 pm ET | Tigers | | Detroit Tigers vs. Chicago White Sox: Photos from Comerica Park |
| Red Sox | 7:10 pm ET | Rays | | Rays playoff hopes in their hands as Red Sox, Yankees come to town |
| Mets | 7:10 pm ET | Reds | | Mets finish off road schedule with three against the Reds |
| Phillies | 7:10 pm ET | Indians | | Phillies must find upgrade at backup catcher this offseason |
| Nationals | 7:10 pm ET | Marlins | | Marlins announce Miguel Rojas, Don Mattingly contract extensions |
| Giants | 7:20 pm ET | Braves | | Braves Clinch, Foltynewicz Dominates, and Ronnie Gets to Bathe in the Bubbly as Braves Beat Giants 6-0 |
| Royals | 8:10 pm ET | Twins | | Gamethread CLV - Royals at Twins |
| Angels | 8:10 pm ET | Astros | | 2019 Season Preview #50: Los Angeles Angels @ Houston Astros |
| Pirates | 8:10 pm ET | Brewers | | Game Thread #154: Milwaukee Brewers (83-70) vs. Pittsburgh Pirates (65-88) |
| Rangers | 10:07 pm ET | Athletics | | 74-80 - You’ll never believe it but the Rangers lost to the A’s |
| Rockies | 10:10 pm ET | Dodgers | | Game no. 154: Peter Lambert vs. Clayton Kershaw |
| Diamondbacks | 10:10 pm ET | Padres | | Diamondbacks RHP Luke Weaver to return from injured list Saturday vs. Padres |
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| Blue Jays | 1:05 pm ET | Yankees | | Gleyber Torres going for MRI on right leg after leaving Yankees game vs. Blue Jays |
| Cardinals | 2:20 pm ET | Cubs | | Chicago Cubs vs. St. Louis Cardinals preview, Saturday 9/21, 1:20 CT |
| Mets | 4:10 pm ET | Reds | | Mets at Reds, Game 2 - Preview and Lineups |
| White Sox | 6:10 pm ET | Tigers | | Detroit Tigers vs. Chicago White Sox: How to watch tonight's game at Comerica Park |
| Red Sox | 6:10 pm ET | Rays | | Daily Wild Card Update: September 21 |
| Nationals | 6:10 pm ET | Marlins | | Marlins vs. Nationals: Start time, how to watch, game thread and Fish Picks—September 21, 2019 |
| Mariners | 7:05 pm ET | Orioles | | Mariners defeat Orioles in 13 innings |
| Royals | 7:10 pm ET | Twins | | Kansas City Royals: Mondesi collects 40th steal in loss to Twins |
| Phillies | 7:10 pm ET | Indians | | Game Thread 9/21: Phillies at Indians |
| Angels | 7:10 pm ET | Astros | | Game Recap: Correa, Pressly make strong returns from injury against the Angels, and the Astros win #101 |
| Pirates | 7:10 pm ET | Brewers | | Milwaukee Brewers pennant race tracker: 8 games to go |
| Giants | 7:20 pm ET | Braves | | Austin Riley starts at first as Braves continue series against Giants |
| Diamondbacks | 8:40 pm ET | Padres | | Merrill Kelly after throwing seven shutout innings vs. Padres |
| Rangers | 9:07 pm ET | Athletics | | After a rough week in Texas, Mike Fiers makes a statement |
| Rockies | 9:10 pm ET | Dodgers | | An ejected Dave Roberts erupts and Dodgers follow suit to rout Rockies |
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| Blue Jays | 1:05 pm ET | Yankees | | Blue Jays break rookie home run record with Billy McKinney’s big day |
| Mariners | 1:05 pm ET | Orioles | | We don't have news for this game |
| White Sox | 1:10 pm ET | Tigers | | Tigers 6, White Sox 3: four home runs back Boyd in Detroit victory |
| Red Sox | 1:10 pm ET | Rays | | Tampa Bay Rays 4, Boston Red Sox 7: Rays can’t rally |
| Mets | 1:10 pm ET | Reds | | Mets at Reds, Game 3 - Preview and Lineups |
| Nationals | 1:10 pm ET | Marlins | | Marlins vs. Nationals: Start time, how to watch, game thread and Fish Picks—September 22, 2019 |
| Giants | 1:20 pm ET | Braves | | Clinch in hand, Keuchel seeks tune-up as Braves go for sweep |
| Royals | 2:10 pm ET | Twins | | Royals vs. Twins Sunday open thread |
| Angels | 2:10 pm ET | Astros | | Another first inning Miley fail dooms Astros. Fall to Angels 8-4. |
| Pirates | 2:10 pm ET | Brewers | | Game Thread #156: Milwaukee Brewers (85-70) vs. Pittsburgh Pirates (65-90) |
| Cardinals | 2:20 pm ET | Cubs | | Cardinals 9, Cubs 8: Craig Kimbrel blows another one |
| Rangers | 4:07 pm ET | Athletics | | 75-81 - Rangers clobber A’s 8-3 for cathartic road finale win |
| Rockies | 4:10 pm ET | Dodgers | | Dodgers 7, Rockies 4: Bellinger leads Dodgers past Rockies with grand slam |
| Diamondbacks | 4:10 pm ET | Padres | | Diamondbacks beat Padres in Rod Barajas' managerial debut |
| Phillies | 6:30 pm ET | Indians | | Game Thread 9/22: Phillies at Indians |
